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Baron-Cohen studied the hypothesis of a deficit of theory of mind and showed that patients with ASD have difficulties in imputing mental states (beliefs, desires, intentions, emotions, etc .) to others[3]

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With the rise of Arabidopsis as a study system, and notably genome sequencing, the pathway and its genes were characterized at the molecular genetic level, revealing (or confirming) that all four enzymes were encoded by more than one gene, thus explaining the presence of the enzyme activities in several compartments (Table 1)

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